Technology

SMART researchers develop gelatin microcarrier for cell production

Researchers from Singapore-MIT Alliance for Research and Technology (SMART), MIT’s research enterprise in Singapore, have developed a novel microcarrier for large-scale cell production and expansion that offers higher yield and cost-effectiveness compared to traditional methods and reduces steps required in the cell retrieval process. Microcarriers are particles used in bioreactor-based cell manufacturing of anchorage-dependent cells. […]

Technology

Penn Researchers Identify Specific Genes and Cell Pathways as Key Players in the Rare Female Lung Disease Lymphangioleiomyomatosis (LAM)

Deleting the TSC2 gene in specific lung cells of mice led to the activation of the mTORC1 signalling pathway and pulmonary disease characteristics consistent with human LAM disease, particularly in female breeder mice. These mice without TSC2 also exhibited a dysfunctional WNT cellular signalling pathway, which is also tied to lung development and is activated in […]

Technology

Drug Screen in 3-D Cell Culture Identifies Promising Lead Against Bladder Cancer Subtype

Researchers at the University of Michigan Rogel Cancer Center have identified a promising targeted therapy against the basal subtype of bladder cancer by screening 3-D cell cultures. MEK inhibitors showed the strongest response against the basal molecular subtype, the research group reported in Oncotarget. Bladder cancer. Image credit: NIH and Peter Choyke, Molecular Imaging Program. “It’s […]

Technology

Understanding mutations at different levels of the cell

Researchers working under ETH-Professor Emeritus Ruedi Aebersold have demonstrated how mutations in a gene influence the structure, function and interaction network of a protein complex. Their work plays a key foundation for personalised medicine. In the wake of proclaiming the “Age of the Genome” in the 1990s, scientists mapped the DNA of many organisms, building […]

Technology

SPOTlight supercharges cell studies | Technology Org

Researchers at Rice University and Baylor College of Medicine have developed a new method to isolate specific cells, and in the process found a more robust fluorescent protein. Both the platform and the protein could be highly useful to synthetic biologists and biomedical researchers. They often need to single out cells with specific visual phenotypes like shape […]