Technology

Alternative gene control mechanism based on organization of DNA within nucleus

Researchers at the University of Tokyo have identified how the architecture of the cell nucleus can change gene activity in plants. This discovery reveals fundamental knowledge about genome regulation and points towards future methods for potentially manipulating the expression of many genes simultaneously. The long strands of DNA and the protein machinery needed to turn […]

Technology

Alternative gene control mechanism based on organization of DNA within nucleus

Researchers at the University of Tokyo have identified how the architecture of the cell nucleus can change gene activity in plants. This discovery reveals fundamental knowledge about genome regulation and points towards future methods for potentially manipulating the expression of many genes simultaneously. The long strands of DNA and the protein machinery needed to turn […]

Technology

Bristol secures £45M to advance gene therapy treatment of chronic kidney diseases

The University of Bristol has secured a £45million deal to advance its groundbreaking gene therapy technology for chronic kidney diseases. The commitment, made by healthcare company Syncona Ltd to Bristol spin-out Purespring Therapeutics, aims to address a global unmet need for renal conditions in one of the largest single investments made to a new UK […]

Technology

Bristol secures £45M to advance gene therapy treatment of chronic kidney diseases

The University of Bristol has secured a £45million deal to advance its groundbreaking gene therapy technology for chronic kidney diseases. The commitment, made by healthcare company Syncona Ltd to Bristol spin-out Purespring Therapeutics, aims to address a global unmet need for renal conditions in one of the largest single investments made to a new UK […]

Technology

A gene mutation that protects against disease

til now, however, the underlying mechanism by which the mutation represented a health benefit other than cardiovascular was a mystery. A surprising protective effect In the new study, the McMaster researchers show that overexpression of this gene variant in the livers of mice who don’t carry PCSK9Q152H had a surprising protective effect against injury and dysfunction […]

Technology

Fujitsu and Tokyo Medical and Dental University Leverage World’s Fastest Supercomputer to Perform Cancer Gene Network Analysis in Less than a Day

Tokyo Medical and Dental University (TMDU) and Fujitsu Laboratories Limited have recently completed, in less than a day, estimation of the network that represents the influence relationship between genes and prediction of their relationship with infiltration and metastasis based on genes highly likely to be involved in cancer development. TMDU and Fujitsu achieved this leveraging […]

Technology

Breakdown of Gene Coordination During Aging Suggests a Substantial Challenge to Longevity

A novel computational method that quantifies for the first time the coordination level between different genes reveals a new hallmark of aging which could require a change of course in current efforts to develop healthy-aging treatments. Image credit: Pixabay (Free Pixabay license) Although all humans share similar changes during aging such as gray hair, wrinkles, […]

Technology

Breakdown of Gene Coordination During Aging Suggests a Substantial Challenge to Longevity

A novel computational method that quantifies for the first time the coordination level between different genes reveals a new hallmark of aging which could require a change of course in current efforts to develop healthy-aging treatments. Image credit: Pixabay (Free Pixabay license) Although all humans share similar changes during aging such as gray hair, wrinkles, […]

Technology

U of A-led research maps gene functions in pancreas cells that lead to diabetes

A team of researchers led by a University of Alberta pharmacology professor has mapped the function and gene expression of individual insulin-producing cells within the human pancreas, opening new paths of research for diagnosing and treating diabetes. “There’s been a lot of excitement the last few years about understanding how pancreatic beta cells make insulin,” said Patrick MacDonald, […]

Technology

U of A-led research maps gene functions in pancreas cells that lead to diabetes

A team of researchers led by a University of Alberta pharmacology professor has mapped the function and gene expression of individual insulin-producing cells within the human pancreas, opening new paths of research for diagnosing and treating diabetes. “There’s been a lot of excitement the last few years about understanding how pancreatic beta cells make insulin,” said Patrick MacDonald, […]