Technology

U of A-led research maps gene functions in pancreas cells that lead to diabetes

A team of researchers led by a University of Alberta pharmacology professor has mapped the function and gene expression of individual insulin-producing cells within the human pancreas, opening new paths of research for diagnosing and treating diabetes. “There’s been a lot of excitement the last few years about understanding how pancreatic beta cells make insulin,” said Patrick MacDonald, […]

Technology

U of A-led research maps gene functions in pancreas cells that lead to diabetes

A team of researchers led by a University of Alberta pharmacology professor has mapped the function and gene expression of individual insulin-producing cells within the human pancreas, opening new paths of research for diagnosing and treating diabetes. “There’s been a lot of excitement the last few years about understanding how pancreatic beta cells make insulin,” said Patrick MacDonald, […]

Technology

Drug Screen in 3-D Cell Culture Identifies Promising Lead Against Bladder Cancer Subtype

Researchers at the University of Michigan Rogel Cancer Center have identified a promising targeted therapy against the basal subtype of bladder cancer by screening 3-D cell cultures. MEK inhibitors showed the strongest response against the basal molecular subtype, the research group reported in Oncotarget. Bladder cancer. Image credit: NIH and Peter Choyke, Molecular Imaging Program. “It’s […]

Technology

New analysis method can lead to better cancer drugs

Membrane proteins are analysed using super-resolution microscopy, a technique limited by the fact that only a small number of membrane proteins – normally three – can be analysed at the same time. Researchers at Karolinska Institutet have now developed a method that increases this number. This non-microscope-based method for analysing entire populations of cells is […]

Technology

New analysis method can lead to better cancer drugs

Membrane proteins are analysed using super-resolution microscopy, a technique limited by the fact that only a small number of membrane proteins – normally three – can be analysed at the same time. Researchers at Karolinska Institutet have now developed a method that increases this number. This non-microscope-based method for analysing entire populations of cells is […]

Technology

Diagnosing Parkinson’s disease with skin samples could lead to earlier detection

New research shows a simple skin test can accurately identify Parkinson’s disease, demonstrating for the first time the feasibility of the method. Currently diagnosed by clinical signs and symptoms but only definitively diagnosed at autopsy, Parkinson’s disease is commonly misdiagnosed early in the disease course, complicating clinical trials of potential treatments. The study, published in the […]

Technology

Diagnosing Parkinson’s disease with skin samples could lead to earlier detection

New research shows a simple skin test can accurately identify Parkinson’s disease, demonstrating for the first time the feasibility of the method. Currently diagnosed by clinical signs and symptoms but only definitively diagnosed at autopsy, Parkinson’s disease is commonly misdiagnosed early in the disease course, complicating clinical trials of potential treatments. The study, published in the […]

Technology

Making AI more ‘explainable’ in health-care settings may lead to more mistakes: U of T researcher

Machine learning algorithms have the potential to provide huge benefits in health care, potentially providing more reliable diagnoses than human doctors in some cases. Yet, many of us are reluctant to entrust our health to an algorithm – especially when even its designers can’t explain exactly how it arrived at its conclusion. This has led to a […]

Technology

Making AI more ‘explainable’ in health-care settings may lead to more mistakes: U of T researcher

Machine learning algorithms have the potential to provide huge benefits in health care, potentially providing more reliable diagnoses than human doctors in some cases. Yet, many of us are reluctant to entrust our health to an algorithm – especially when even its designers can’t explain exactly how it arrived at its conclusion. This has led to a […]