Problems in synapse connection sites found in rare neurodevelopmental disorders

CASK-related neurodevelopmental disorders are caused by mutations affecting the CASK gene and result in a variety of symptoms ranging from brain abnormalities to severe intellectual disability or autism spectrum disorder. Currently, there are no specific treatments for CASK-related disorders. In the published study, the researchers used genetic, molecular, cellular, and functional methods to investigate neuronal mechanisms related to CASK-related neurodevelopmental […]