Technology

Interdisciplinary melanoma research brings understanding of cellular resistance to cancer treatment, opening doors to new cures

A Vanderbilt cancer systems biology team has identified the enzymes that keep tumor cells growing in the presence of drug treatment, opening the door to stopping these cells dead in their tracks. An article, “An Integrative Gene Expression and Mathematical Flux-Balance Analysis Identifies Targetable Redox Vulnerabilities in Melanoma Cells,” was published in the journal Cancer Research. Until […]

Technology

Interdisciplinary melanoma research brings understanding of cellular resistance to cancer treatment, opening doors to new cures

A Vanderbilt cancer systems biology team has identified the enzymes that keep tumor cells growing in the presence of drug treatment, opening the door to stopping these cells dead in their tracks. An article, “An Integrative Gene Expression and Mathematical Flux-Balance Analysis Identifies Targetable Redox Vulnerabilities in Melanoma Cells,” was published in the journal Cancer Research. Until […]

Technology

Imaging technique could replace tissue biopsies in assessing drug resistance in breast cancer patients

Imaging techniques could replace the need for invasive tissue biopsies in helping rapidly determine whether cancer treatments are working effectively, according to researchers at the University of Cambridge. In a study published in the journal Cancer Cell, researchers at the Cancer Research UK (CRUK) Cambridge Institute have shown how a new technique known as hyperpolarisation – […]

Technology

Imaging technique could replace tissue biopsies in assessing drug resistance in breast cancer patients

Imaging techniques could replace the need for invasive tissue biopsies in helping rapidly determine whether cancer treatments are working effectively, according to researchers at the University of Cambridge. In a study published in the journal Cancer Cell, researchers at the Cancer Research UK (CRUK) Cambridge Institute have shown how a new technique known as hyperpolarisation – […]

Technology

New wave of medical ‘deep tech’ can help coronavirus response – but there’s resistance

The development of new medical technologies based on cutting-edge discoveries has accelerated during the coronavirus pandemic and is helping us respond to the health crisis. But for these technologies to flourish, attitudes and scepticism among investors still need to change, say researchers and start-ups. Research institutions such as synchrotron X-ray facilities have shifted their work […]

Technology

NHS implements antifungal resistance test

Research funded by the NIHR Manchester Biomedical Research Centre (BRC) has led to UK-wide implementation of a novel NHS diagnostic test that uses pyrosequencing (a method of identifying genetic markers in DNA), to identify the right treatment for people with aspergillosis. Aspergillosis is an infection caused by the Aspergillus mould. The disease is rare in healthy people […]

Technology

Study reveals a novel strategy for using compounds as ‘anti-evolution’ drugs to combat antibiotic resistance

The rise of antibiotic resistance in many pathogens has been driven by the spread of a small number of strains, suggesting that some bacteria may be genetically pre-disposed to evolving resistance. Researchers at Oxford University have tested this hypothesis by quantifying differences in evolvability between pathogen strains and by searching for ‘potentiator’ genes that accelerate […]